产地 | 美国 |
品牌 | Abbiotec |
货号 | 250798 |
保存条件 | -20℃ |
用途 | 科研 |
应用范围 | E, IHC, WB |
抗原来源 | |
CAS编号 | |
保质期 | 一年 |
抗体名 | OAT-1 |
是否单克隆 | 否 |
克隆性 | |
靶点 | |
适应物种 | M R |
形态 | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 50% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. |
宿主 | Rabbit |
标记物 | |
包装规格 | 0.1mg |
纯度 | % |
亚型 | IgG |
标识物 | |
浓度 | % |
免疫原 | KLH-conjugated synthetic peptide encompassing a sequence within the center region of mouse OAT-1. |
是否进口 | 是 |
产品背景Description
The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds.
别名Alternate Names
Solute carrier family 22 member 6; Organic anion transporter 1; OAT1; Renal organic anion transporter 1; ROAT1; Novel kidney transcript; NKT; SLC22A6
应用说明Application Notes
E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
引用文献Product Citations
[1] Naud J et al. 2011. Drug Metabolism and Disposition. 39(8):1363-1369. PMID# 21525170. [2] Eisner C et al. 2012. Kidney International. 77:519-526. PMID# 20032962.