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- 电 话：0755-26055215
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- 地 址：深圳市南山区创业路中兴工业城5栋518
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- 品牌：Abbiotec
- 产地：美国
- 货号：254542
- 发布日期： 2021-01-15
- 更新日期： 2024-04-19
| 抗体名 | YAP1 |
| 是否单克隆 | 否 |
| 用途范围 | E WB |
| 形态 | Each vial contains 0.1 ml IgG in PBS pH7.4, 1 mg/ml BSA, 50% glycerol, and 0.1% sodium azide. |
| 宿主 | Rabbit |
| 纯度 | % |
| 免疫原 | KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1. |
| 产地 | 美国 |
| 品牌 | Abbiotec |
| 货号 | 254542 |
| 保存条件 | -20℃ |
| 应用范围 | E WB |
| 保质期 | 一年 |
| 规格 | 0.1ml |
| 产品用途 | 科研 |
| 适应物种 | H M R |
| 亚型 | IgG |
| 浓度 | % |
| 是否进口 | 是 |
产品背景Description
YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.
别名Alternate Names
Yorkie homolog; 65 kDa Yes-associated protein; YAP65; YAP1; Transcriptional coactivator YAP1; Yes-associated protein 1; Yes associated protein YAP65 homolog
应用说明Application Notes
YAP1 (Ser94) Antibody recognizes endogenous and transfected levels of YAP1 when phosphorylated at Ser94 (Ser79 in mouse and rat). E: 1:5,000-1:20,000; WB: 1:1,000-1:10,000
引用文献Product Citations
Mo J-S. et al. 2015. Nature Cell Biology. 17(3): 500-10. PMID# 25751140.
