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YAP1 (Ser94)抗体
物品单位 品牌
Abbiotec
  • 产地:美国
  • 货号:254542
  • 发布日期: 2021-01-15
  • 更新日期: 2021-01-15
产品详细说明
CAS编号
抗体名 YAP1
是否单克隆
靶点
用途范围 E WB
形态 Each vial contains 0.1 ml IgG in PBS pH7.4, 1 mg/ml BSA, 50% glycerol, and 0.1% sodium azide.
宿主 Rabbit
标记物
纯度 %
免疫原 KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1.
产地 美国
品牌 Abbiotec
货号 254542
保存条件 -20℃
应用范围 E WB
抗原来源
保质期 一年
规格 0.1ml
产品用途 科研
克隆性
适应物种 H M R
亚型 IgG
标识物
浓度 %
是否进口

产品背景Description 

YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.



别名Alternate Names 

Yorkie homolog; 65 kDa Yes-associated protein; YAP65; YAP1; Transcriptional coactivator YAP1; Yes-associated protein 1; Yes associated protein YAP65 homolog



应用说明Application Notes 

YAP1 (Ser94) Antibody recognizes endogenous and transfected levels of YAP1 when phosphorylated at Ser94 (Ser79 in mouse and rat). E: 1:5,000-1:20,000; WB: 1:1,000-1:10,000


引用文献Product Citations 

Mo J-S. et al. 2015. Nature Cell Biology. 17(3): 500-10. PMID# 25751140.