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- 品牌:Abbiotec
- 产地:美国
- 货号:251265
- 发布日期: 2021-01-15
- 更新日期: 2023-09-28
抗体名 | KISS1 |
是否单克隆 | 否 |
用途范围 | E IHC WB |
形态 | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. |
宿主 | Rabbit |
纯度 | % |
免疫原 | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KISS1. |
产地 | 美国 |
品牌 | Abbiotec |
货号 | 251265 |
保存条件 | -20℃ |
应用范围 | E, IHC, WB |
保质期 | 一年 |
规格 | 0.1mg |
产品用途 | 科研 |
适应物种 | H M R |
亚型 | IgG |
浓度 | % |
是否进口 | 是 |
产品背景
KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
别名Alternate Names
Metastasis-suppressor KiSS-1; Kisspeptin-1; KiSS-1; Metastin; Kisspeptin-14; Kisspeptin-13; Kisspeptin-10; KISS1
应用说明Application Notes
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
引用文献Product Citations
[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140. [2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704. [3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.