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| 产地 | 美国 |
| 品牌 | Abbiotec |
| 货号 | 251265 |
| 保存条件 | -20℃ |
| 用途 | 科研 |
| 应用范围 | E, IHC, WB |
| 抗原来源 | |
| CAS编号 | |
| 保质期 | 一年 |
| 抗体名 | KISS1 |
| 是否单克隆 | 否 |
| 克隆性 | |
| 靶点 | |
| 适应物种 | H M R |
| 形态 | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. |
| 宿主 | Rabbit |
| 标记物 | |
| 包装规格 | 0.1mg |
| 纯度 | % |
| 亚型 | IgG |
| 标识物 | |
| 浓度 | % |
| 免疫原 | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KISS1. |
| 是否进口 | 是 |
产品背景
KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
别名Alternate Names
Metastasis-suppressor KiSS-1; Kisspeptin-1; KiSS-1; Metastin; Kisspeptin-14; Kisspeptin-13; Kisspeptin-10; KISS1
应用说明Application Notes
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
引用文献Product Citations
[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140. [2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704. [3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.
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