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KISS1抗体
物品单位 品牌
Abbiotec
  • 产地:美国
  • 货号:251265
  • 发布日期: 2021-01-15
  • 更新日期: 2021-01-15
产品详细说明
CAS编号
抗体名 KISS1
是否单克隆
靶点
用途范围 E IHC WB
形态 Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide.
宿主 Rabbit
标记物
纯度 %
免疫原 KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KISS1.
产地 美国
品牌 Abbiotec
货号 251265
保存条件 -20℃
应用范围 E, IHC, WB
抗原来源
保质期 一年
规格 0.1mg
产品用途 科研
克隆性
适应物种 H M R
亚型 IgG
标识物
浓度 %
是否进口

产品背景

KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.


别名Alternate Names 

Metastasis-suppressor KiSS-1; Kisspeptin-1; KiSS-1; Metastin; Kisspeptin-14; Kisspeptin-13; Kisspeptin-10; KISS1



应用说明Application Notes 

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500



引用文献Product Citations 

[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140. [2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704. [3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.