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Angiotensin II(血管紧张素Ⅱ)抗体
物品单位 品牌
Abbiotec
  • 产地:美国
  • 货号:251229
  • 发布日期: 2021-01-15
  • 更新日期: 2022-09-16
产品详细说明
CAS编号
抗体名 Angiotensin II
是否单克隆
靶点
用途范围 E, IHC, WB
形态 Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide.
宿主 Rabbit
标记物
纯度 %
免疫原 KLH-conjugated MAP synthetic peptide corresponding to human angiotensinogen II.
产地 美国
品牌 Abbiotec
货号 251229
保存条件 -20℃
应用范围 E, IHC, WB
抗原来源
保质期 一年
规格 0.1mg
产品用途 科研
克隆性
适应物种 H M R
亚型 IgG
标识物
浓度 %
是否进口

产品背景

Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.



别名Alternate Names 

Ang-II; Ang II; Angiotensin II; Angiotensin-2; AGT; Angiotensinogen; Serpin A8



应用说明Application Notes 

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500


引用文献Product Citations 

[1] Zhang H et al. 2017. J Neuroimmunol. PMID 29169800. [2] Guo W et al. 2016. PLoS One. 11(4): e0153434. PMID 27073902. [3] Wang C. et al. 2015. J Cardiovasc Pharmacol. 66(3):285-293. PMID 25955575. [4] Wang C et al. 2015. Acta Biochim Biophys Sin. PMID 26071572. [5] Matsuura-Hachiya Y et al. 2013. Biochem. Biophys. Res. Commun. 442(1-2):34-43. PMID 24216112.