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gps1573 peptide
  • 品牌:ABBIOTEC
  • 产地:美国
  • 货号:350595
  • 价格: ¥询价/1 mg
  • 发布日期: 2019-07-31
  • 更新日期: 2024-02-26
产品详请
产地 美国
品牌 ABBIOTEC
货号 350595
保存条件 store at -20°C
保质期 两年个月
GPS1573 is a newly described potent and dose-dependent peptide antagonist of ACTH-stimulated melanocortin type 2 receptor (MC2R) activity in vitro (IC50 = 66 nM). GPS1573 antagonizes MC4R with IC50 of 950 nM, therefore showing selectivity for MC2R. The binding of ACTH to MC2R regulates steroidogenesis leading to metabolic diseases such as Cushing's disease in patients with pituitary dysfunctions.H-Nle-Pro-(D-Phe)-Arg-(D-Trp)-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 or H-Nle-PfRwFKAVGKKRR-NH2