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rfrp-3 peptide
物品单位 价格 品牌
1 mg 询价 ABBIOTEC
  • 产地:美国
  • 货号:350591
  • 发布日期: 2019-07-31
  • 更新日期: 2019-07-31
产品详细说明
产地 美国
品牌 ABBIOTEC
货号 350591
保存条件 store at -20°C
英文名称
CAS编号
保质期 两年个月
RFamide-related peptides (RFRP-1 and RFRP-3) belong to a group of RFamide peptides, which have an arginine-phenylalanine-amide structure at the C-term end. RFRPs share a similar C-term sequence with neuropeptide FF (NPFF) and have a relatively high affinity to GPR147 (also called NPFF1 receptor, RFRP receptor or OT7T022). RFRP-1 facilitates prolactin release from the pituitary and attenuates morphine-induced analgesia. RFRP-3 inhibits the gonadotrophin-releasing hormone neuron-luteinising hormone system in mammals and increases food intake. RFRP-1 and RFRP-3 are derived from the same preprotein (Pro-FMRFamide-related neuropeptide VF) and are co-expressed in single neurons in the dorsomedial hypothalamus, which plays a pivotal role in the control of stress responses in neuroendocrine, autonomic and behavioral systems. RFRP-3 inhibits forskolin-stimulated cAMP production in CHO cells expressing OT7T022 (ED50=0.7 nM).Human: H-Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2 or H-VPNLPQRF-NH2