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cd61 peptide
- 品牌:ABBIOTEC
- 产地:美国
- 货号:350573
- 价格: ¥询价/0.1 mg
- 发布日期: 2019-07-31
- 更新日期: 2024-07-26
产品详请
产地 | 美国 |
品牌 | ABBIOTEC |
货号 | 350573 |
保存条件 | store at -20°C |
保质期 | 两年个月 |
CD61, also called integrin beta-3, belongs to the integrin protein family that participates in cell adhesion and cell-surface mediated signalling by forming heterodimers of alpha and beta integrin chains. Integrin alpha-V/beta-3 is a receptor for cytoactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. These two integrins recognize the sequence RGD in a wide array of ligands. Integrin IIb/IIIa recognizes the sequence HHLGGGAKQAGDV in fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 supports platelet/platelet interaction through binding of soluble fibrinogen, leading to rapid platelet aggregation which physically plugs ruptured endothelial surface. Defects in CD61 are a cause of Glanzmann thrombasthenia, a blot clot disorder.The synthetic peptide used to raise the antibody Cat. No. 250732 is selected from a sequence within the C-term region of human CD61. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.