Adipocyte enhancer-binding protein 1 (AEBP1) up-regulates MAP-kinase activity leading to enhanced proliferation and reduced differentiation of the adipocyte. AEBP1 also up-regulates NF-kappa-B activity in macrophages via phosphorylation and subsequent degradation of I-kappa-B-alpha. This leads to enhanced macrophage inflammatory responsiveness. It can also act as a transcriptional repressor.The synthetic peptide used to raise the antibody Cat. No. 200198 is selected from a sequence within the N-term region of AEBP1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.