Proto-oncogene tyrosine-protein kinase receptor ret (C-ret) is a tyrosine kinase receptor for DOK2, 4 and 5 important in development. Defects in C-ret are a cause of pheochromocytoma, thyroid carcinoma, neoplasia and neural crest development disorders.The synthetic peptide used to raise the antibody Cat. No. 200171 is selected from a sequence within the C-term region of human RET. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.