MUTYH is involved in oxydative DNA damage repair by initiating repair of A-oxoG to C-G by removing the inappropriately paired adenine base from the DNA backbone. Defects in MUTYH are the cause of colorectal and gastric cancers.The synthetic peptide used to raise the antibody Cat. No. 200157 is selected from a sequence within the C-term region of human MUTYH. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.