Merlin (NF2) acts as a membrane stabilizing protein and may inhibit PI3 kinase by binding to CENTG1. Defects in NF2 are the cause of neurofibromatosis 2 and schwannnomatosis (neuromas).The synthetic peptide used to raise the antibody Cat. No. 200156 is selected from a sequence within the C-term region of human NF2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.