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bmpr1a peptide
  • 品牌:ABBIOTEC
  • 产地:美国
  • 货号:350513
  • 价格: ¥询价/0.1 mg
  • 发布日期: 2019-07-31
  • 更新日期: 2024-06-14
产品详请
产地 美国
品牌 ABBIOTEC
货号 350513
保存条件 store at -20°C
保质期 两年个月
Upon ligand binding, BMPR1A forms a receptor complex consisting of two type II and two type I transmembrane Ser/Thr kinases. The type I receptors are activated by the type II receptors by using a phosphorylation mechanism, and subsequently bind SMAD transcriptional regulators. Defects in BMPR1A are the cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2, which lead to gastrointestinal, breast, thyroid, endometrial and colon cancers.The synthetic peptide used to raise the antibody Cat. No. 200151 is selected from a sequence within the N-term region of human BMPR1A. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.