Neurofibromin (NF1) stimulates the GTPase activity of Ras. Defects in NF1 are the cause of different types neurofibromatosis, colorectal cancer, and juvenile myelomonocytic leukemia.The synthetic peptide used to raise the antibody Cat. No. 200150 is selected from a sequence within the center region of human NF1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.