CDK4, a CMGC Ser/Thr protein kinase, is involved in the control of the cell cycle by forming a stable complex with D-type G1 cyclins. Defects in CDK4 are the cause of melanoma.The synthetic peptide used to raise the antibody Cat. No. 200148 is selected from a sequence within the C-term region of human CDK4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.