Glypican-3 (GPC3) is a cell surface proteoglycan that bears heparan sulfate. GPC3 is likely involved in the modulation of growth in the predominantly mesodermal tissues and organs. Defects in GPC3 are the cause of pre- and postnatal overgrowth (gigantism, Simpson-Golabi-Behmel syndrome).The synthetic peptide used to raise the antibody Cat. No. 200135 is selected from a sequence within the N-term region of human Glypican-3. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.