Axin2 is an inhibitor of the Wnt signaling pathway and down-regulates beta-catenin. Defects in Axin2 are the cause of colorectal cancer.The synthetic peptide used to raise the antibody Cat. No. 200133 is selected from a sequence within the N-term region of human AXIN2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.