SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions.The synthetic peptide used to raise the antibody Cat. No. 200127 is selected from a sequence within the N-term region of human SPHK1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.