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perk peptide
物品单位 | 价格 | 品牌 |
---|---|---|
0.1 mg | 询价 | ABBIOTEC |
- 产地:美国
- 货号:350479
- 发布日期: 2019-07-31
- 更新日期: 2022-12-29
产品详细说明
产地 | 美国 |
品牌 | ABBIOTEC |
货号 | 350479 |
保存条件 | store at -20°C |
英文名称 | |
CAS编号 | |
保质期 | 两年个月 |
PERK, a Ser/Thr protein kinase, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. Defects in PERK are the cause of Wolcott-Rallison syndrome, an early-onset diabetes mellitus.The synthetic peptide used to raise the antibody Cat. No. 200117 is selected from a sequence within the C-term region of human PERK. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.