PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.The synthetic peptide used to raise the antibody Cat. No. 200116 is selected from a sequence within the C-term region of human PDK4. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.