OAS1 is involved in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent Rnase L to cleaves single-stranded RNAs.The synthetic peptide used to raise the antibody Cat. No. 200114 is selected from a sequence within the N-term region of human OAS1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.