KIT is the receptor for stem cell factor (mast cell growth factor). KIT has a tyrosine protein kinase activity. Defects in KIT are a cause of piebaldism (lack of melanocytes), gastrointestinal stromal tumors and testicular tumors.The synthetic peptide used to raise the antibody Cat. No. 200111 is selected from a sequence within the C-term region of human KIT. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.