IGF1R binds insulin-like growth factor 1 (IGF1) with high affinity and IGF2 with low affinity. The receptor has a tyrosine protein kinase activity necessary for the activation of the IGF1-stimulated downstream signaling cascade.The synthetic peptide used to raise the antibody Cat. No. 200109 is selected from a sequence within the C-term region of human IGF1R. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.