syvn1 peptide
- 发布日期: 2019-07-31
- 更新日期: 2025-05-16
产品详请
产地 |
美国
|
品牌 |
ABBIOTEC
|
货号 |
350470
|
保存条件 |
store at -20°C
|
英文名称 |
|
CAS编号 |
|
保质期 |
两年个月
|
Synoviolin (SYVN1) acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates subsequently promoting their degradation. For instance, SYVN1 protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. SYVN1 is up-regulated in synovial tissues from patients with rheumatoid arthritis.The synthetic peptide used to raise the antibody Cat. No. 200108 is selected from a sequence within the C-term region of human SYVN1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.