[arg3,14] ctx iv [3-14] peptide
- 发布日期: 2019-07-31
- 更新日期: 2025-05-09
产品详请
产地 |
美国
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品牌 |
ABBIOTEC
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货号 |
350432
|
保存条件 |
store at -20°C
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英文名称 |
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CAS编号 |
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保质期 |
两年个月
|
[Arg3,14] CTX IV [3-14] Peptide sequence corresponds to aa3-14 of the Cytotoxin IV (CTX IV), a toxin expressed by the venom gland of the Egyptian cobra. CTX IV has cytolytic activity on many different cells by forming pore in lipid membrane. CTX IV is a monomer in solution and forms homodimer and oligomer in the presence of negatively charged lipids forming a pore with a size ranging between 20 and 30 A. The toxin increases heart rate and kills the animal by cardiac arrest. The LD50 is 4.0 mg/kg by intravenous injection. CTX IV also binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independant manner, and binds to integrin alpha-V/beta-3 with moderate affinity.H-Arg-Asn-Arg-Leu-Ile-Pro-Pro-Phe-Trp-Lys-Thr-Arg-NH2 or H-RNRLIPPFWKTR-NH2