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thrombin receptor agonist peptide
物品单位 | 价格 | 品牌 |
---|---|---|
1 mg | 询价 | ABBIOTEC |
- 产地:美国
- 货号:350404
- 发布日期: 2019-07-31
- 更新日期: 2023-06-07
产品详细说明
产地 | 美国 |
品牌 | ABBIOTEC |
货号 | 350404 |
保存条件 | store at -20°C |
英文名称 | |
CAS编号 | |
保质期 | 两年个月 |
Thrombin signaling of platelets is mediated by a G protein-coupled protease-activated receptor (PAR). The PAR is activated after thrombin binding and subsequent cleavage of the amino terminal end of the receptor. This new amino terminus acts as a tethered ligand and binds intramolecularly to the body of the PAR, resulting in a transmembrane signal. A synthetic thrombin receptor agonist peptide (TRP) of 6 residues (SFLLRN) corresponding to aa42-47 of the thrombin receptor was found to be as effective as thrombin for Ca2+ mobilization. TRAP can be used instead of thrombin to trigger platelet aggregation and clot retraction.Human: H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH or H-SFLLRNPNDKYEPF-OH