thrombin receptor agonist peptide
- 发布日期: 2019-07-31
- 更新日期: 2025-05-09
产品详请
产地 |
美国
|
品牌 |
ABBIOTEC
|
货号 |
350404
|
保存条件 |
store at -20°C
|
英文名称 |
|
CAS编号 |
|
保质期 |
两年个月
|
Thrombin signaling of platelets is mediated by a G protein-coupled protease-activated receptor (PAR). The PAR is activated after thrombin binding and subsequent cleavage of the amino terminal end of the receptor. This new amino terminus acts as a tethered ligand and binds intramolecularly to the body of the PAR, resulting in a transmembrane signal. A synthetic thrombin receptor agonist peptide (TRP) of 6 residues (SFLLRN) corresponding to aa42-47 of the thrombin receptor was found to be as effective as thrombin for Ca2+ mobilization. TRAP can be used instead of thrombin to trigger platelet aggregation and clot retraction.Human: H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH or H-SFLLRNPNDKYEPF-OH