plp [139-151] peptide
- 发布日期: 2019-07-31
- 更新日期: 2025-05-29
产品详请
产地 |
美国
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品牌 |
ABBIOTEC
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货号 |
350349
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保存条件 |
store at -20°C
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英文名称 |
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CAS编号 |
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保质期 |
两年个月
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The PLP [139-151] peptide from the myelin proteolipid protein (PLP) has been found to be highly immunogenic in inducing experimental allergic encephalomyelitis (EAE) in SJC/J (H-2s) mice as part of an autoimmune response. The sequence is derived from PLP with a cysteine residue replaced by a serine. The peptide is conserved in mouse, rat, monkey, dog, pig, bovine and found to be similar in chicken, frog, turtle except for the first two residues. Mouse T-cell clones that are reactive with the peptide have been developped, and variations on the different clones' ability to elicit the immune response have been used to understand mechanisms of T-cell function. Later work has devised analogs of this peptide that block the immune response in vitro and in vivo, with implications for the regulation of autoimmune diseases.Human: H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH or H-HSLGKWLGHPDKF-OH