MEN-10376 is a potent and selective NK2 tachykinin receptor antagonist. MEN-10376 displays > 250-fold selectivity over NK1 and NK3. NK2 receptors mediate contractile effects in the human small intestine and colon circular muscle strips.H-Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2 or H-DYwVwwK-NH2