CaMK2a (CAMKII alpha, CaM Kinase 2 alpha) is a prominent Ser/Thr kinase in the central nervous system thatfunctions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling complex at the excitatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.The synthetic peptide used to raise the antibody Cat. No. 250569 is selected from a sequence within the C-term region of human CaMK2a. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.