oat-1 peptide
- 发布日期: 2019-07-31
- 更新日期: 2025-07-08
产品详请
产地 |
美国
|
品牌 |
ABBIOTEC
|
货号 |
300115
|
保存条件 |
store at -20°C
|
英文名称 |
|
CAS编号 |
|
保质期 |
两年个月
|
The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds. The synthetic peptide used to raise the antibody Cat. No. 250797 is selected from a sequence within the center region of human OAT-1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.