Aromatase (cytochrome P450 19A1) catalyzes the formation of aromatic C18 estrogens from C19 androgens. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This aromatase localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens.The synthetic peptide used to raise the antibody Cat. No. 250549 is selected from a sequence within the N-term region of human Aromatase. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.