Type II collagen (COL2A1) is specific for cartilaginous tissues. Type II collagen is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Defects in COL2A1 are the cause of a variety of chondrodysplasia including hypochondrogenesis and osteoarthritis.The synthetic peptide used to raise the antibody Cat. No. 250484 is selected from a sequence within the center region of human type II collagen. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.