T淋巴细胞膜蛋白3TIM3
背景描述Description：
T淋巴细胞膜蛋白3(TIM3)存在于T辅助细胞1型淋巴细胞和其他免疫细胞，包括树突状细胞和自然杀伤细胞。TIM3在CD4+肿瘤浸润淋巴细胞中过表达，包括与预后不良相关的非小细胞肺癌。TIM3最近成为肿瘤免疫 的潜在靶点。
T-cell Immunoglobulin and Mucin-Domain-Containing Molecule-3 (TIM3) is present on T-helper type 1 lymphocytes and other immune cells including dendritic cells and natural killer cells. TIM3 is overexpressed in CD4+ tumor-infiltrating lymphocytes, including those with non-small cell lung cancer associated with poor prognoses. TIM3 has recently emerged as a potential target for cancer

immunotherapy.

Specifications：
Clone: IHC003
Source: Mouse Monoclonal
Positive Control: Tonsil
Dilution Range: 1:100 - 1:400

参考文献References:
Monney L, et al. Nature. 2002; 415:536-41.
Sánchez-Fueyo A, et al. Nat Immunol. 2003; 4:1093-101.
Anderson AC. Cancer Immun Res. 2014; 2:393–8.
Gao X, et al. PLoS One. 2012; 7:e30676.