PD-L1
背景描述Description：
PD-L1又称CD274或B7同源物1(B7-H1)，是一种跨膜蛋白，通过与程序性死亡-1(PD-1)受体的结合，抑制，使细胞抵抗CD8+T细胞介导的杀伤。PD-L1的过度表达可能使癌细胞逃避宿主的作用。在中，PD-L1的表达上调与侵袭性和死亡风险增加有关，而在中，PD-L1的高表达会导致明显的不良预后。PD-L1还与和皮肤有关。当与CD8+浸润淋巴细胞密度联合考虑时，PD-L1的表达水平可能是预测多种类型的有用指标，包括III期非小细胞、激素受体阴性和前哨淋巴结。
Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.

Specifications：
Clone IHC411
Source Rabbit Monoclonal
Positive Control Tonsil, Lung Adenocarcinoma
Dilution Range 1:50-1:200

参考文献References:
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