Nerve Growth Factor Receptor (NGFR)
背景描述Description：
神经生长因子受体(NerveGrowthFactor Receptor，NGFR)又称p75、P-75NTR或CD271，是受体家族中的一种神经营养因子受体。NGFR主要表达于雪旺细胞和神经元，以及其他一些非神经细胞类型，在中枢和周围发育过程中发挥。神经生长因子受体也在黑素细胞、、神经母细胞瘤、嗜铬细胞瘤、神经、神经化痣(C型黑素细胞)及其他神经嵴细胞或衍生物中表达。NGFR可能是和尿路上皮癌的抑制因子，抗神经生长因子受体(anti-nervegrowthfactorreceptor，NGFR)常与S100结合使用，以辅助诊断促结缔组织增生性和神经营养性恶性。
Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and neurons, as well as a number of other non-neuronal cell types, and functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed in melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives. It has been suggested that NGFR may act as a tumor suppressor indicated in prostate and urothelial cancer, and Anti-Nerve Growth Factor Receptor (NGFR) is often used in adjunct with S100, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas. Anti-NGFR is also useful as an aid in the diagnosis of breast malignancy, as the antibody labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts.

Specifications
Clone IHC637
Source Mouse Monoclonal
Positive Control Breast
Dilution Range 1:50-1:200

参考文献References：
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