HER2/neu
背景描述Description：
Her2/Neu(c-erbB-2)原癌基因是一种跨膜受体酪氨酸激酶，广泛存在于多种中。c-erbB-2蛋白的过度表达与乳腺导管癌、肺腺癌和胃腺癌有关。Her2和p53之间的相关性也已被证实，因为这两种蛋白的过度表达与的早期侵袭和转移有关。
The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the c-erbB-2 protein has been associated with ductal breast cancer, as well as pulmonary and gastric adenocarcinomas. A correlation between Her2 and p53 has also been documented, as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.

Specifications：
Clone IHC042
Source Mouse Monoclonal
Positive Control Breast Carcinoma
Dilution Range 1:50-1:200

参考文献References：
Suthipintawong C, et al. Diagn Cytopathol. 1997; 17:127-33.
Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.
Fernández Ace?ero MJ, et al. Gen Diagn Pathol. 1997; 142:289-96.
Koeppen HKW, et al. Histopathology. 2001; 38:96-104.
Moch H, et al. Virchows Arch A Pathol Anat Histopathol. 1993; 423:329-34.
Cetin B, et al. Transl Gastroenterol Hepatol. 2016; 1:59.