CD57
背景描述Description：
ClusterofDifferentiation57，CD57又称NK-1，是一种可在自然杀伤细胞、部分T淋巴细胞和正常外周血单个核细胞、髓系细胞以及多种多肽、脂类和硫酸软骨素蛋白多糖中检测到的抗原。CD57是一种神经来源的标志物，包括嗜铬细胞瘤、副神经节瘤、类癌和髓母细胞瘤，以及各种神经，包括神经瘤、神经、神经鞘瘤和颗粒细胞瘤。CD57在神经节细胞瘤和中也有表达。抗CD57抗体用于鉴别性淋巴细胞性霍奇金与T细胞/组织细胞丰富的大B细胞、性硬化型和滤泡性。
Cluster of differentiation 57 (CD57), also known as NK-1, is an antigen detectable in natural killer cells, some T-lymphocytes and normal peripheral blood mononuclear cells, myeloid cells, and a variety of polypeptides, lipids, and chondroitin sulfate proteoglycans. CD57 is indicated as a marker for tumors of neuroendocrine origin, including pheochromocytomas, paragangliomas, carcinoid tumor, and medulloblastomas, as well as various neural tumors including neuromas, neurofibromas, schwannomas, and granular cell tumors. CD57 is also detectable in ganglioneuroma and prostate carcinoma. Anti-CD57 is used to distinguish nodular lymphocyte-predominant Hodgkin’s lymphoma from T-cell/histiocyte-rich large B-cell lymphoma, nodular sclerosis Hodgkin’s disease, and follicular lymphoma.

Specifications：
Clone                 IHC539
Source                 Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:50-1:200

参考文献References：
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