产品货号Reference:             CAN-E-7000
检测方法Kit Type:                Competitive LIA
规格Kit Size:                         96-well break-apart microplate
灵敏度Sensitivity:                1.2 pg/mL
检测样本Sample Type:         Human saliva / 100 μL
校准范围Calibrator Range:  2–300 pg/mL
检测时间Total Assay Time:  90 minutes
背景介绍：
雌酮是一种类似雌三醇和雌二醇的类固醇，属于雌激素类。雌激素参与了女性性器官的发育和第二性征的发生。在卵子受精之前，雌激素的主要作用是对生殖道的生长和功能的影响，以便为受精的卵子做好准备。
在月经周期的卵泡期，雌酮水平略有升高。雌酮的产量随后显著增加，在周期的*3天达到高峰。峰值持续时间短，到*6天的周期水平将会很低。第二个高峰出现在周期的第21天左右，如果不进行受精，雌酮的产量就会减少。雌酮的测定有助于监测卵巢功能，预测排卵，评估促排卵的效果。
唾液中雌酮的测定是血浆分析的一种有吸引力的替代方法，因为它的非侵入性、无应力程序使连续取样变得容易。一些研究似乎证实，唾液中的雌酮浓度与血浆中未结合的雌酮浓度相近，因此提供了一个更准确的活动指标。
Estrone is a steroid like estriol and estradiol, belonging to the class of estrogens. The estrogens are involved in the development of female sex organs and secondary sex characteristics. Before the ovum is fertilized the main action of the estrogens is on the growth and function of the reproductive tract in order to prepare it for the fertilized ovum.
During the follicular phase of the menstrual cycle the estrone level shows a slight increase. The production of estrone then increases markedly to peak at around day 13 of the cycle. The peak is of short duration and by day 16 of the cycle levels will be low. A second peak occurs at around day 21 of the cycle and if fertilization does not occur, then the production of estrone decreases. The measurement of estrone is useful for monitoring ovarian function, in predicting ovulation, in assessing the effect of therapy to induce ovulation.
The measurement of estrone in saliva is an attractive alternative to plasma analysis because its non-invasive, stress-free procedure makes serial sampling easy. Some research appears to confirm that estrone concentrations in saliva approximate the unbound-estrone in plasma therefore provide a more accurate indication of endocrine activity.

注：本产品仅用于科研用途，不能直接用于人体或临床诊断使用。