Hamartin (TSC1) is involved in vesicular transport and docking with TSC2. Hamartin is a tumor suppressor. Defects in hamartin are the cause of tuberous sclerosis complex (TSC), a multi-system disorder.The synthetic peptide used to raise the antibody Cat. No. 200146 is selected from a sequence within the C-term region of human hamartin. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.