Tissue inhibitor of metalloproteinases 3 (TIMP-3) binds to metalloproteinases such as collagenases and irreversibly inactivates the proteases. TIMP-2 is involved in the extracellular matrix remodeling by binding to MMP-1, -2, -3, -7, -9, -13, -14 and -15. Defects in TIMP-3 are the cause of Sorsby fundus dystrophy (SFD), a macular disorder leading to vision loss.The synthetic peptide used to raise the antibody Cat. No. 250885 is selected from a sequence within the C-term region of human TIMP-3. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.