产品货号Reference:              CAN-SHBG-4010
检测方法Kit Type:                 Sandwich ELISA
规格Kit Size:                         96-well break-apart microplate
灵敏度Sensitivity:                 0.1 nmol/L
检测样本Sample Type:         Human serum / 10 μL
校准范围Calibrator Range:  3.3–295 nmol/L
检测时间Total Assay Time:  60 minutes

背景介绍：
性激素结合球蛋白(SHBG)是由373个氨基酸残基和3个糖链组成的糖蛋白。SHBG被命名为睾酮-雌二醇结合球蛋白(TeBG)、性类固醇结合蛋白(SBP)和性类固醇结合球蛋白(SSBG)。其主要特性之一是其对甾体的高亲和力，尤其是C18、C19和17个α-羟基。甾体与SHBG的结合具有温度和pH依赖性。对SHBG有高亲和力的三种类固醇是双氢睾酮、睾酮和雌二醇。极少量的类固醇在生物液中是游离的；大多数是与SHBG和白蛋白结合的。当SHBG浓度变化时，无论是白蛋白结合的激素还是游离部分，都发生了显著的变化。
Sex hormone binding globulin (SHBG) is a glycoprotein composed of 373 amino acid residues and three carbohydrate side chains. SHBG has been known by many other names including Testosterone-estradiol Binding Globulin (TeBG), Sex steroid Binding Protein (sBP) and Sex Steroid Binding Globulin (SSBG). One of the main properties of SHBG is its high affinity for steroids, especially the C18, C19 and 17α-hydroxyl groups. The binding of steroids to SHBG is temperature and pH dependent. The three steroids that have a high avidity for SHBG are Dihydrotestosterone, Testosterone and Estradiol. Very small amounts of these steroids are free in biological fluid; the majority are bound to SHBG and albumin. These two fractions, that is, free and bound exist in a state of dynamic equilibrium. When the level of SHBG concentration changes, a remarkable change occurs in both albumin-bound hormone and also in the free fraction.